This article presents results of the analysis of 3 NPS: clephedrone (4-CMC), 4-chloroethcathinone (4-CEC), and brephedrone (4-BMC) on recreational drug markets and a systematic review of all the available information concerning these substances. It presents the possibility that the emergence of these substances is the next step in the cat-and-mouse game existing between drug producers and legislation.


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