Buspirone interacion whith some drugs
im on a new anxiolytic called buspar (buspirone), and i was wondering if it’ll have any interactive effects with marijuana, MDMA, DMT, or LSD??? There are no studies available about clinical interactions between buspirone and psychedelic drugs. Buspirone acts partially on serotoninergic receptors 5-HT1A and decreases effects of serotonin-releasing drugs as fluoxetine. So it is possible that effects of MDMA, DMT or LSD should be diminished. In theory, effects of marijuana should not...
Read MoreDMT long term effects
I was wondering if you knew of any long term effects (postive or negative) from DMT use (heavy or not). As many other “classical psychedelics” organic toxicity of DMT is practically nonexistent. There are no reported cases of intoxication resulting in acute death. Lethal dosage is calculated based in animal models and it seems a reasonably secure drug. There are no reports about neurotoxicity, cardiotoxicity, hepatotoxicity or damage to other human organs, not even in animal administration. Problems of long-term or acute DMT are of psychological nature. For some people it...
Read MoreDMT and methadone interactions
with the above post in mind do you know of any complications with taking DMT and methadone maintenance? Or what about complications with taking MAOIs like Caapi vine or syrian rue in ayahuasca when on methadone maintenance? There are no known interactions between methadone and DMT. But methadone is a phenylpiperidine derivative and these molecules have serotoninergic activity. At least in theory, it is possible an interaction between methadone and MAOIs, at least in large doses or susceptible individuals. MAOIs used in ayahuasca are not, in general, very potent. But MAOIs have important...
Read MoreSt John’s wort and DMT interactions
what if i mixed St Johns Wort with smoked DMT? Hypericum perforatum (St John´s Wort) acts as an antidepressant. There are many drugs that can interact with this plant, and some of these interactions are relevant. Hypericum elevates serotonin levels and may contribute to serotonin syndrome. As far as I know there are no reported cases of this problem as a result of the combination of St John´s Wort and tryptamines or phenethylamines. But there are cases with drugs with similar mechanism of action. http://www.ncbi.nlm.nih.gov/pubmed/17868285 http://www.ncbi.nlm.nih.gov/pubmed/15666281...
Read MoreDMT use in mental health problems
A friend is interested in trying DMT after I recently introduced her boyfriend to it. There is a history of schizophrenia in her family while she herself has been diagnosed as being on the autistic spectrum. She is also currently diagnosed with depression and an anxiety disorder. Do you think DMT might be particularly hazardous for her and, if reasonably safe, are there any special precautions that should be taken? Yes, in this case, the use of DMT or other psychedelics is formally contraindicated. Use of these substances is not recommended and /or familiar history of schizophrenia....
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