by DoctorX | Nov 27, 2017 | Doctor X files, Pharmacological tolerance
What exactly is substance tolerance? How does it work? Does the brain shutdown some receptors? For example, why does the same dose today have a weaker effect if taken tomorrow? Drug tolerance is a commonly encountered effect in pharmacology, it is...
by DoctorX | Nov 5, 2017 | Doctor X files, Pharmacological tolerance
I am currently taking abilify (not sure on the dose, maybe ~5mg), Wellbutrin (I think 75mg), and cymbalta (60mv morning, 30mg at night) and I’m wondering how these will affect drug use. I’ve been experimenting with DMT and 25i-NBOMe and have noticed...
by DoctorX | Nov 4, 2017 | Doctor X files, Pharmacological tolerance
I’m on the medication for depression and anxiety, which certain psychedelic drugs seem to help a little bit. I’m not on antipsychotics for anything like bipolar disorder or schizophrenia so, correct me if I’m wrong, but I feel like it is safe...
by DoctorX | Aug 28, 2016 | Doctor X files, Pharmacological tolerance
I’m having a difficult time actually getting visuals when taking LSD or the 2c family (2c-e, 2c-p, 2c-b). Only connection I can come up with is the fact that I did DMT a few days prior, but again the 2nd time I did LSD I didn’t do DMT for about a...
by DoctorX | Aug 25, 2016 | Doctor X files, Pharmacological tolerance
Does opioid tolerance last a lifetime? More specifically if someone was regularly taking opioids for years, developed a high tolerance, but was able to withdraw and stay off for several years – would the tolerance remain? Or would it return more quickly...
