Tolerance definition

  What exactly is substance tolerance? How does it work? Does the brain shutdown some receptors? For example, why does the same dose today have a weaker effect if taken tomorrow?     Drug tolerance is a commonly encountered effect in pharmacology, it is...

Tolerance to opiates

  Does opioid tolerance last a lifetime?  More specifically if someone was regularly taking opioids for years, developed a high tolerance, but was able to withdraw and stay off for several years – would the tolerance remain?  Or would it return more quickly...

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