Pharmacological tolerance

Tolerance definition

Posted by in Doctor X files, Pharmacological tolerance

  What exactly is substance tolerance? How does it work? Does the brain shutdown some receptors? For example, why does the same dose today have a weaker effect if taken tomorrow?     Drug tolerance is a commonly encountered effect in pharmacology, it is a progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration., requiring an increase in concentration to achieve the desired effect. Tolerance is reversible, and its rate depends on the characteristics of each particular drug. Some drugs create tolerance more quickly...

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Psychedelic tolerance under prescription drugs

Posted by in Doctor X files, Pharmacological tolerance

  I am currently taking abilify (not sure on the dose, maybe ~5mg), Wellbutrin (I think 75mg), and cymbalta (60mv morning, 30mg at night) and I’m wondering how these will affect drug use. I’ve been experimenting with DMT and 25i-NBOMe and have noticed reduced effects and reduced visuals. I’ve also noticed with 25i I need to take larger doses (~4-5mg) to feel some effects with limited visual effects. I also plan on trying 2-CE soon.So my question is, are these diminished effects normal for someone taking the medication that I’m on? How can I get more pronounced effects...

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Psychedelics cross tolerance

Posted by in Doctor X files, Pharmacological tolerance

  I’m on the medication for depression and anxiety, which certain psychedelic drugs seem to help a little bit. I’m not on antipsychotics for anything like bipolar disorder or schizophrenia so, correct me if I’m wrong, but I feel like it is safe for me to use psychedelics.I have one more question. On the part about counteracting the effects of the medication by increasing psychedelic dosage, is this safe to do with DMT? Also, is there any cross tolerance between 2C-X, NBOMe series, and DMT?     Increasing the dosage of DMT could increase the risk of bad psychological...

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Psychedelics cross-tolerance

Posted by in Doctor X files, Pharmacological tolerance

  I’m having a difficult time actually getting visuals when taking LSD or the 2c family (2c-e, 2c-p, 2c-b). Only connection I can come up with is the fact that I did DMT a few days prior, but again the 2nd time I did LSD I didn’t do DMT for about a week. My question is do they work on the same receptors or does the DMT effect the trip of LSD/2c family? Some things I also noticed is when I did 2c-b/LSD, I would get a cramp on my upper trapezius muscle but when I did DMT during the LSD I it would just go away. Additionally I should mention that I have type 1 diabetes which is well...

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Tolerance to opiates

Posted by in Doctor X files, Pharmacological tolerance

  Does opioid tolerance last a lifetime?  More specifically if someone was regularly taking opioids for years, developed a high tolerance, but was able to withdraw and stay off for several years – would the tolerance remain?  Or would it return more quickly than in someone who never had a tolerance?   Tolerance does not last a lifetime. Depending of family of substances it lasts more or less time. For opiates, it is necessary weeks or months to significantly reduce tolerance. In some months tolerance diminish practically to levels of people who never had used substance. In persons with...

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