Neurotoxicity

Neurotoxicity of MDMA and 2C-X

Posted by in Doctor X files, Neurotoxicity

  Comparatively, how bad would you say psychedelic phenethylamines are compared to MDMA? I’ve been reading a lot about phenethylamines lately and how they can boost the body’s metabolism, induce the feeling of love, and possibly improve cognitive function and mood. On a personal level, I can say that after consuming a variety of different 2C-x compounds at lower doses, I’ve never had adverse after-effects, which I cannot say for MDMA. 2C-I, 2C-E, and other 2C-x compounds seem to utilize a more of a pay-it-forward approach, where you feel like shit on the come-up (not unlike...

Read More

Nitrous and LSD neurotoxicity

Posted by in Doctor X files, Neurotoxicity

  I have a more specific question concerning N2O (mixed with other substances like LSD).Over the last couple of months it has become somewhat if a ritual for me to induce myself into an LSD trip once or twice a month, very often with the assistance of short nitrous oxide “flashes”.Now I know the effects it creates: Next to light headedness, slight euphoria and halluzinogenic coloring, I get a strong visual and sonic “echoing”. Visual in the case that it’s like you are only able to see one still picture, and after the effects of the N2O slowly wear off, more and...

Read More

Amphetamine neurotoxicity

Posted by in Doctor X files, Neurotoxicity

  How long would u have to abuse street-amphetamines (not meth the normal amps) and how often until you damage your neurons ?   Amphetamine can produce neurotoxic effects. There are clear evidences about this both in animals and humans. But it is very difficult to know the toxic dosage and pattern of use. Amphetamine has been used as therapeutic drug up to 40 mg/daily dosage (oral route) without evidence of neurotoxicity in long time. Intranasal or intravenous route probably enhance the possibility of neurotoxicity. The purity (or presence of toxic adulterants) of street amphetamine is...

Read More

Methylone dosage and neurotoxicity

Posted by in Doctor X files, Neurotoxicity

  My question: I was using MDMA once a month and decided to start alternating with methylone (one month MDMA, the next month methylone), in order to reduce the serotonine depletion, because I understand methylone works relatively more on dopamine than on serotonine. My methylone dosage on the other hand is always quite a bit higher than my MDMA dosage (250mg MDMA vs 400mg methylone, spread over the night) I realize methylone is not as well studied as MDMA, but I have never experienced any adverse reactions or bad comedowns or after effects, so I am not worried about that. My main concern is...

Read More

Dextroamphetamine and neurotoxicity

Posted by in Doctor X files, Neurotoxicity

  What makes you believe that dextroamphetamine is not neurotoxic at therapeutic dosages?   Dosages of dextroamphetamine that produce neurotoxicity are much higher than those used in human therapeutics. In animal experiments dosages are between 20-60 mg/kg injected. That would be 1.2-3.6 gr of injected d-amphetamine for humans. In animals, these dosages produce neurotoxicity but also death caused by hyperthermia of most specimens. These effects are not seen in humans. http://www.sciencedirect.com/science/article/pii/S0006899398008464...

Read More

Amphetamine and neurotoxicity

Posted by in Doctor X files, Neurotoxicity

  I am prescribed dexedrine and ritalin. Would it be a good idea to combine the two drugs to counteract amphetamine neurotoxicity?   Neurotoxicity of dextroamphetamine is only manifested at very high dosages in some animal models. Dosages used in human prescription are under neurotoxic levels. Methylphenidate (Ritalin) neurotoxic potential is even lower, insignificant, according to studies. http://www.ncbi.nlm.nih.gov/pubmed/9365033 http://www.ncbi.nlm.nih.gov/pubmed/22289608 http://www.ncbi.nlm.nih.gov/pubmed/2440058 So neurotoxicity should not be a matter of concern, considering oral route...

Read More

Pin It on Pinterest