Drug interactions

Buspirone interactions whith some drugs 2

Posted by in Doctor X files, Drug interactions

  im wondering about mescaline and buspar (buspirone)? i read somewhere that cocaine mixed with buspar can cause seizures.. and since mescaline is a semi-stimulant, i was wondering about it.   There are not many data about this particular. Buspirone does not act as an stimulant. Effects, adverse effects, toxicity and effects of overdosing are not that from stimulants. Anyway, there is little research about combination between psychedelic and prescription drugs. I do not recommend to use psychedelics while on therapeutic drugs. If you are doing so it is important to be very careful with...

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DMT and methadone interactions

Posted by in Doctor X files, Drug interactions

  with the above post in mind do you know of any complications with taking DMT and methadone maintenance? Or what about complications with taking MAOIs like Caapi vine or syrian rue in ayahuasca when on methadone maintenance?   There are no known interactions between methadone and DMT. But methadone is a phenylpiperidine derivative and these molecules have serotoninergic activity. At least in theory, it is possible an interaction between methadone and MAOIs, at least in large doses or susceptible individuals. MAOIs used in ayahuasca are not, in general, very potent. But MAOIs have important...

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St John’s wort and DMT interactions

Posted by in Doctor X files, Drug interactions

  what if i mixed St Johns Wort with smoked DMT?     Hypericum perforatum (St John´s Wort) acts as an antidepressant. There are many drugs that can interact with this plant, and some of these interactions are relevant. Hypericum elevates serotonin levels and may contribute to serotonin syndrome. As far as I know there are no reported cases of this problem as a result of the combination of St John´s Wort and tryptamines or phenethylamines. But there are cases with drugs with similar mechanism of action. http://www.ncbi.nlm.nih.gov/pubmed/17868285 http://www.ncbi.nlm.nih.gov/pubmed/15666281...

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Benzodiacepines, antipsychotics and GHB/GBL interactions

Posted by in Doctor X files, Drug interactions

  My question concerns GBL/GHB and using prescription drugs. I use a (Seroxat or Optibar are the brand names.) SSRI 40mg in the morning and Seroquel 300mg in the evening for mental illnesses. Very randomly I use klonazepam 2mg in the evening to relax. I know this is dodgy, using drugs while using depression/anxiety medication, but this is my situation. The question is, if/when I make GHB from GBL and start using it, does it interfere with SSRI, Seroquel or random benzos? Or do I even make bigger risks with this combination and I shouldn’t use it at all? In any case I will use proper...

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GHB and cocaine interactions

Posted by in Doctor X files, Drug interactions

  I have a general question regarding the combination of GHB and cocaine, my research has yielded quite contradictory results. The common stance seems to be that any combination of a cns depressant and stimulant will put undue strain on the cardio-vascular system, but I also found information that would consider this combination health-beneficial. Some characteristics of GHB found on Erowid:  low toxicity, relatively few contraindications, slowing of the heart rate without loss of blood pressure, muscle relaxation, absence of respiratory depression, reduction of body temperature, and various...

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Benzodiacepines and methaqualone interactions

Posted by in Doctor X files, Drug interactions

  Doc, is mixing benzo’s with Quaaluudes dangerous?     Methaqualone is a drug sedative–hypnotic activity. This can be enhanced by the use of benzos. The risk of excessive sedation, respiratory depression or coma is higher mixing these methaqualone and benzos, obviously depending on dosage and potency  

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