Psychedelics cross-tolerance

Posted by in Doctor X files, Pharmacological tolerance

 

I’m having a difficult time actually getting visuals when taking LSD or the 2c family (2c-e, 2c-p, 2c-b). Only connection I can come up with is the fact that I did DMT a few days prior, but again the 2nd time I did LSD I didn’t do DMT for about a week. My question is do they work on the same receptors or does the DMT effect the trip of LSD/2c family? Some things I also noticed is when I did 2c-b/LSD, I would get a cramp on my upper trapezius muscle but when I did DMT during the LSD I it would just go away. Additionally I should mention that I have type 1 diabetes which is well controlled (A1C has been in the range of 6-6.5 for the past 10 years).

Also is there any other long term health concerns other than serotonin syndrome with psychedelics? Thanks for your time!

 

There is some degree of cross-tolerance between most “classical” psychedelics. Most of them are phenethylamines or tryptamines that act interacts in different ways in 5-HT2A serotoninergic receptors. When tolerance to hallucinogenic effects is developed with one member of the family, this effects appears for most similar substances. One week is not time enough to make this effect of tolerance disapear. Several weeks/a month is the minimum time to make this tolerance disappear.

In general, LSD, DMT and 2C-x family are relatively safe in a physical way.

If your diabetes is well controlled and you take normal precautions, there are no additional risks and your risk are similar to those of non-diabetic persons.

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