Comparatively, how bad would you say psychedelic phenethylamines are compared to MDMA? I’ve been reading a lot about phenethylamines lately and how they can boost the body’s metabolism, induce the feeling of love, and possibly improve cognitive function and mood. On a personal level, I can say that after consuming a variety of different 2C-x compounds at lower doses, I’ve never had adverse after-effects, which I cannot say for MDMA. 2C-I, 2C-E, and other 2C-x compounds seem to utilize a more of a pay-it-forward approach, where you feel like shit on the come-up (not unlike mescaline), but then just feel amazing through the trip and without any sort of ill-effects in the come-down. Can psychedelic phenethylamines potentially cause damage akin to what MDMA does to Nigral cells? Could you start burning holes in to your brain if you took psychedelic phenethylamines a few too many times, or are they fairly safe when compared to MDMA?
There is no evidence that occasional, moderate use of MDMA can cause permanent neurologic damage. Studies that show neurotoxic effects for MDMA are based in animal models or extremely intensive human users. So, in this sense, MDMA is a more studied molecule than 2C-X, in which there is a lack of human investigation. Some 2C-X (-B, -I, -E) have been used during decades without knowledge of significant negative effects and are probably safe. Other are newer and potentially dangerous (2C-Bfly) or contain atoms rarely seen in human pharmacology (2C-C. 2C-F, 2C-SE). Anyway, it is true that after-effects or “comedown” related to MDMA is harder than 2C-X for most people. But it does not necessarily mean that reasonable use of MDMA leads to neurotoxicity