For someone who hasn’t used Ecstasy in 8 years and has never taken pure MDMA, what would you suggest as a dosage? What if this person wants to mix it with an NBOMe? Is that stupid? How much of each?
Clinical trials with MDMA in humans use dosages between 80-150 mg. In healthy persons with no medical contraindications, that should be considered the reasonable dosage. On the other hand, there are no clinical trials with NBOMEs in humans. In fact there are only a few studies on cloned neurorreceptors of rabbits and pigs (no joking). Using NBOMEs is potentially far more dangerous than MDMA or classical psychedelics. There is no “safe dosage”, even less in combination