What would the consequence of using MDMA and Cocaine in the same night be?
The consequences would depend on many factors: timing, dosage of each substance, frequence of administration… and personal and environmental factors also.
In general a variable degree of hyperstimulation could be expected. For most people MDMA and cocaine is not a pleasant combination, as cocaine reduces empathogenic effects of MDMA. But it also a matter of personal taste…In any case, high dosages of both substances make unpleasant effects (tachicardia, hypertension, anxiety, dry moutth…) more likely and intense