DMT and methadone interactions

Posted by in Doctor X files, Drug interactions

 

with the above post in mind do you know of any complications with taking DMT and methadone maintenance? Or what about complications with taking MAOIs like Caapi vine or syrian rue in ayahuasca when on methadone maintenance?

 

There are no known interactions between methadone and DMT. But methadone is a phenylpiperidine derivative and these molecules have serotoninergic activity. At least in theory, it is possible an interaction between methadone and MAOIs, at least in large doses or susceptible individuals. MAOIs used in ayahuasca are not, in general, very potent. But MAOIs have important interactions with other psychoactives and this combination should be avoided or managed with extreme caution. http://bja.oxfordjournals.org/content/95/4/434.full

 

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