Amphetamine and neurotoxicity

Posted by in Doctor X files, Neurotoxicity

 

I am prescribed dexedrine and ritalin.

Would it be a good idea to combine the two drugs to counteract amphetamine neurotoxicity?

 

Neurotoxicity of dextroamphetamine is only manifested at very high dosages in some animal models. Dosages used in human prescription are under neurotoxic levels. Methylphenidate (Ritalin) neurotoxic potential is even lower, insignificant, according to studies.

http://www.ncbi.nlm.nih.gov/pubmed/9365033

http://www.ncbi.nlm.nih.gov/pubmed/22289608

http://www.ncbi.nlm.nih.gov/pubmed/2440058

So neurotoxicity should not be a matter of concern, considering oral route and common prescription dosages and pattern of use. Combining both will have no effect in terms neurotoxicity (as it is unlikely that it exists) but it will increase adverse effects associated to this family as anxiety, anorexia, tachycardia, restlessness.. .

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